By Dr. Forest Tennant
Using Objective Signs of Severe Pain to Guide Opioid Prescribing
A Commonsense Diagnostic Approach
It is often said that pain treatment must be guided only by subjective perceptions of the patient
and that pain itself cannot be objectively assessed. This belief is only partially correct.
It is clearly humane to ask patients about their pain perceptions and to grade their pain on the
standard 1-to-10 scale. However, the practitioner who must separate relief-seekers from drug-seekers
when prescribing potent opioid analgesics needs to use objective measures to accomplish this critical task.
The diagnostic approach proposed here entails commonsense medical practice. The fact is that severe,
uncontrolled pain usually produces more objective physical evidence of its presence than does
the average case of diabetes or coronary artery disease.
Pain is a potent stressor that activates the entire sympathetic nervous system and the
hypothalamus-pituitary-adrenal axis to produce high serum levels of catecholamines and glucocorticoids.1-6
Since this is a physiologic reaction, some simple objective measures of adrenal and sympathetic responses,
including pulse rate, blood pressure, and pupil size are easy to assess.
The practitioner also should perform an examination to evaluate if the pain is uncontrolled, as well as to
determine if severe pain has been present for an extended period of time. For example, severe,
chronic pain may cause an afflicted person to find physical positioning relief and avoid sensory
inputs that may worsen the pain. And, some sufferers will attempt to distract their attention from the area
that hurts to another site by physical maneuvers.
The physical signs described here are categorized as relating to sympathetic discharge, positional relief,
sensory avoidance, and pain distraction. For convenience, each of these categories is in table form
on the following pages to readily assist healthcare providers.
Uncontrolled, severe pain can almost always be
identified by objective physical signs that help
practitioners differentiate between drug-seekers and
relief-seekers, as well as to determine if opioid
dose is adequate.
Signs of Sympathetic Discharge
Sympathetic, or adrenergic, discharge is caused by two concomitant mechanisms. Adrenergic
receptors in the central nervous system are activated by uncontrolled pain, and these
central receptors in turn activate the autonomic nervous system by sending electrical impulses
downward into the periphery via the vagus nerve and the autonomic nerve network.7-9 The
second mechanism is activation of the hypothalamic-pituitary-adrenal axis and the out-pouring
of catecholamines (adrenaline, dopamine, and noradrenaline) and glucocorticoids (pregnenolone,
cortisol) into the blood stream.5-7 Findings of excess sympathetic discharge can be detected in
both acute and chronic uncontrolled pain. (Tables 1 & 2.)
The author has frequently heard the comment that sympathetic discharge signs are only present
with acute pain, but these signs occur with any uncontrolled pain. Signs of sympathetic discharge
even can be detected in non-verbal or comatose patients, such as infants or bedbound
elderly. While not all of the sympathetic discharge signs are present in every patient,
elevated pulse rate, hypertension, dilated pupils, vasoconstriction, and diaphoresis are almost
always seen in patients whose pain has elevated above a critical threshold that is
biologically specific to that person. Sympathetic discharge signs can be quickly and easily assessed
in clinical practice. Medical or nursing assistants, and even the patient, can take a blood pressure
and pulse rate that can be verified by the practitioner. A simple stroking of hands or feet can detect
vasoconstriction (cold to the touch), and a light touch of skin under the eyes is a good place to feel the
moisture of excess sweating. Examining pupils will require that fluorescent lights are turned off – normal
pupil diameter is approximately 3.0 mm to 5.0 mm.
The author recommends that patients with severe, chronic pain should have a target pulse rate less
than 88 beats per minute and blood pressure below 130/90 mm Hg. (Table 2.)
At-Home Blood & Pulse Monitoring
Chronic pain has a baseline or persistent component, as do breakthrough pain or pain
flares. For this reason, patients should be taught to take their BP and pulse at home when
breakthrough pain or flares occur. This can be done using modern BP/pulse monitoring devices
that can be obtained inexpensively at most pharmacies or large retail outlets.
TABLE 1
Sympathetic Discharge Signs
Tachycardia
High Blood Pressure
Dilated Pupils
Vasoconstriction (Cold Hands or Feet)
Diaphoresis
Hyperreflexia
Insomnia
Nausea
Diarrhea
Anorexia
Table 2
Recommended Objective Measures to Help Determine
Uncontrolled Pain & Opioid Overmedication
UNCONTROLLED PAIN GOOD PAIN CONTROL EXCESS OPIOIDS
Pulse rate Pulse between Pulse Rate
> 88 beats per minute 64 to 88 beats per minute 130/90 mm Hg 110/70 and 130/90 mm Hg 5.0 mm 3.0 and 5.0 mm < 3.0 mm
Cold hands or feet Normal temperature Very warm hands or feet
Patients should keep an ongoing record and bring this to their practitioner for review.
This way, healthcare providers can determine if their medical regimen is effectively
controlling pain when the patient is outside the clinical setting. Additionally, patients
and their families need to know that severe, chronic pain raises blood pressure and/or pulse rate,
and that these elevations may lead to cardiovascular complications such as coronary artery disease
and cerebral vascular accidents (strokes).
Once patients and families observe that blood pressure and pulse rate go up with pain intensity,
it is easy for the practitioner to instruct them that a rise in adrenaline and cortisol is occurring, and that
these effects may produce elevated blood lipids and glucose that may hasten the development of
arteriosclerosis and/or diabetes. Essentially, chronic pain of enough severity will cause sympathetic
discharge and this physiologic phenomenon is a profound cardiovascular risk.10-13
Signs of Positional Relief
Patients who “hurt” during certain movements or physical functions will naturally attempt to avoid the pain
by finding a comfortable position. They may do this over a period of months to years and leave telltale physical
signs that are easily observable, but might be overlooked if the practitioner is not alert to them. (Table 3.)
In its simplest form positional relief is present in the patient who walks with a limp, drags a foot, or walks offbalance.
Other signs can be observed in the patient who leans in one direction to relieve back pain, or in the
headache patient who frowns on one side. In these cases a permanent crease on one side of the back or
forehead can be detected. If the patient seeks positional relief long enough, some muscle groups hypertrophy to
compensate for the extra load while others may atrophy due to minimal use. Patients who walk
abnormally to seek pain relief may have one shoe sole that wears down in one spot compared
with the opposite shoe.
The basic physiologic problem with long-term attempts to use positional relief is that some
body parts become asymmetrical. Rather than a balance of two equal sides, one side becomes
overused with subsequent muscle hypertrophy and possibly degeneration of joints. For example,
a patient with a painful right knee may typically over-weight and over-use the left hip and
knee, which may lead to degenerative arthritis and pain in the left hip and
knee that is secondary to the original pain.
The side of the body that was originally in pain – and thus favored and
underused – will undergo muscle atrophy and possibly contractures. For example,
a patient with a severe, painful neuropathy in one extremity may develop
permanent atrophy and contractures to the point that the extremity is
functionless. The atrophic side will often become cool to the touch as circulation also apparently decreases in the area.
Fundamentally, the practitioner should look for physical, objective signs of asymmetry when
evaluating a chronic pain patient. Unless severe pain is controlled, physical signs of asymmetry
in affected areas of the body will invariably emerge over time.
TABLE 3
Common Positional Relief Signs
Walks imbalanced, wide gait, foot drag or limp
(shoes don’t wear evenly)
Leans while sitting or standing
Lies on floor
Sits on edge of chair
Looks straight ahead (won’t turn head)
One shoulder raised or lowered
Forehead crease on one side
Muscle hypertrophy or atrophy of back muscles
Difference in temperature between sides
NOTE: These are all signs of body asymmetry.
Chronic pain of enough severity will cause sympathetic
discharge and this physiologic phenomenonis a profound cardiovascular risk.
Unless severe pain is controlled, physical signs of
asymmetry in affected areas of the body will invariably emerge.
Signs of Sensory Avoidance
Closely related to positional relief is sensory avoidance.
The obvious example of sensory avoidance involves a painful area that gets even more painful with
touch. Uncontrolled pain hyper-stimulates the autonomic nervous system, so practically any sensory
input may cause additional pain. (Table 4.)
The classic case is the migraine patient who turns out the lights, lays alone in a room, and covers their
head and eyes. This patient may hurt worse with any sensory input, including light, noise, smell, eating, or
movement.
Some extremely painful conditions such as reflex sympathetic dystrophy (also called chronic regional pain
syndrome), adhesive arachnoiditis, and diabetic peripheral neuropathy produce such pain that even light touch
is unbearable (allodynia). In these cases, patients may not wear clothes or allow a sheet to cover themselves.
They may not wear shoes or socks. Patients with neuropathies of the face, head, and neck may not brush their
teeth, shave, or comb their hair. Any attempt by the examiner to touch the affected area will be met with
immediate withdrawal of the body part and a sudden “no” response from the patient.
Patients with painful conditions of the upper torso, including fibromyalgia, abdominal adhesions,
or cervical spine conditions may speak slowly, softly, and with hesitancy – for fear that a
forceful voice and the effort of speaking might produce more pain. Often patients in severe pain
will sit on the edge of their chair and stare straight ahead, because leaning back or turning their
head is painful. Patients with spinal or abdominal diseases may breath so slow and shallow
that their carbon dioxide (CO2) levels increase.2
Signs of Pain Distraction
Patients in severe pain may not only attempt to avoid sensory input and find positional relief, they also may
attempt maneuvers or techniques to distract their attention away from their pain. These can sometimes be
physically observed by the practitioner. (Table 5.)
Grinding of the teeth can sometimes be detected by whittled-down teeth. Lip biting and fist clenching are
common. Less commonly observed is overheating of a painful area with a hot water bottle or heating pad.
Sometimes permanently mottled skin or actual burns can be observed. Rarely, some patients
become so tortured with pain that they will bang their head, fist, or foot against a wall, and the
trauma of this activity may be evident. Cigarette burns or cuts may be intentionally self-inflicted.
TABLE 4
Common Sensory Avoidance Signs
Speaks slowly, softly, hesitantly
Wears sunglasses / stays in dark
Delays answering questions
Wears hat (to shield scalp, hair)
Walks slowly, deliberately and with wide gait,
limp, or foot drag
Stares or looks straight ahead
Avoids noise
Shallow breathing
Doesn’t eat or drink
Wears loose or no clothes over painful areas
Won’t brush teeth, shave, or comb hair
TABLE 5
Common Pain Distraction Signs
Grinds/grits teeth
Clenches knuckles/toes
Overheats skin (may show permanent burn marks)
Hits head, fist, or foot against wall
Cigarette burns or cuts
Bites lips
Gouges or squeezes skin
Importance of Physical Signs in Guiding Opioid Dosing
In most medical practices today, in addition to legitimate pain-relief-seekers, who are the
majority, there can be opioid-drug-seekers with less genuine intentions. During the initial
evaluation of all new patients they should be physically examined for the objective, physical
signs of legitimate pain that are described above.
If none are found, nonopioid treatments should be satisfactory for pain treatment. If a practitioner
encounters a questionable patient, the patient’s close family members can usually verify
behavioral signs compatible with positional relief, sensory avoidance, or pain distraction attempts.
Experienced drug-seekers may be able to fake certain signs of severe pain during an
office visit, but would not consistently exhibit such behaviors with family members.
Patients who are receiving ongoing, outpatient opioid treatment will periodically require an
adjustment in opioid dosage. Increases in dosages usually should be prescribed if the patient’s
complaints of uncontrolled pain are confirmed by evidence of excess sympathetic discharge
such as tachycardia, hypertension, cold hands/feet, or dilated pupils.
For example, a patient who states his/her pain is an 8 out of 10, and demonstrates a pulse
rate of 100 and pupil dilation greater than 5.0 mm, warrants a higher opioid dosage or an additional
opioid. Conversely, if the same patient demonstrates a normal blood pressure, pulse
rate, and pupil size, an adjustment in opioid dosage might be postponed for later evaluation. In
this case, daily at-home tracking of pulse and blood pressure by the patient and an interview
with the family could be in order.
Summary
The objective, physical signs of excess sympathetic discharge, sensory
avoidance, positional relief, and pain distraction should be sought by physical
examination in every pain patient. In this way, complaints of severe pain by a
patient can be confirmed by objective physical signs. While it is imperative
that patients (and possibly family members) should be interviewed as to their
perception of pain’s severity, pain that is above a critical threshold for each
individual produces objective, physical signs that can be even more evident
than the usual physical signs of such common disorders as diabetes and
coronary artery disease.
.
A search for objective, physical signs of excess sympathetic discharge, sensory avoidance,
Positional relief, and pain distraction should be part of the physical examination
of every pain patient.
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About the author:
Forest Tennant, MD, DrPH attended the University of Kansas Medical School and served in the United States
Public Health Service, assigned to the UCLA School of Public Health as an academic research fellow. In 1975
he started the Veract Intractable Pain Clinic in West Covina, CA, initially focusing on cancer and postpolio patients.
Dr. Tennant has published more than 200 scientific articles and pioneered research on the complications
and treatment of intractable pain. He helped sponsor the California Intractable Pain Act and the Pain Patients
Bill of Rights. He is Editor in Chief Emeritus of the journal Practical Pain Management. Dr. Tennant has
no conflicting interests to declare relating to the subject of this paper